| 1. Round | 16/01/2022 | Luis Ángel Firpo | - | Municipal Limeño | 1:0 | ||||
| 2. Round | 23/01/2022 | Municipal Limeño | - | Platense Zacatecoluca | 2:1 |  |
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| 3. Round | 26/01/2022 | Once Municipal | - | Municipal Limeño | 3:2 | |
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| 4. Round | 30/01/2022 | Municipal Limeño | - | CD Águila | 0:3 | |
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| 5. Round | 04/02/2022 | Jocoro FC | - | Municipal Limeño | 3:0 | ||||
| 9. Round | 23/02/2022 | Municipal Limeño | - | Atlético Marte | 2:0 | |
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| 10. Round | 27/02/2022 | Isidro Metapán | - | Municipal Limeño | 2:0 | ||||
| 11. Round | 06/03/2022 | Municipal Limeño | - | AD Chalatenango | 0:1 | ||||
| 17. Round | 13/04/2022 | FAS | - | Municipal Limeño | 1:1 | |
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| 19. Round | 24/04/2022 | Alianza | - | Municipal Limeño | 4:0 | |
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| 20. Round | 27/04/2022 | Atlético Marte | - | Municipal Limeño | 0:1 | ||||
| 21. Round | 01/05/2022 | Municipal Limeño | - | Isidro Metapán | 1:0 | |
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| 22. Round | 07/05/2022 | AD Chalatenango | - | Municipal Limeño | 0:0 |
El Salvador