| 1. Round | 19/09/2021 | UE Engordany | - | CE Carroi | 3:1 |  |
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| 2. Round | 26/09/2021 | FC Santa Coloma | - | UE Engordany | 1:1 | |
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| 3. Round | 03/10/2021 | UE Engordany | - | UE Sant Julià | 1:1 | |
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| 4. Round | 17/10/2021 | Inter Club d'Escaldes | - | UE Engordany | 3:0 | |
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| 5. Round | 24/10/2021 | UE Engordany | - | Atlétic Escaldes | 0:2 | |
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| 7. Round | 07/11/2021 | UE Engordany | - | FC Ordino | 2:4 | |
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| 8. Round | 21/11/2021 | CE Carroi | - | UE Engordany | 1:4 | ||||
| 9. Round | 28/11/2021 | UE Engordany | - | FC Santa Coloma | 2:4 |  |
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| 10. Round | 19/12/2021 | UE Sant Julià | - | UE Engordany | 3:2 | ||||
| 11. Round | 03/02/2022 | UE Engordany | - | Inter Club d'Escaldes | 1:2 | ||||
| 15. Round | 13/02/2022 | UE Engordany | - | CE Carroi | 1:0 | ||||
| 16. Round | 20/02/2022 | FC Santa Coloma | - | UE Engordany | 1:1 | |
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| 17. Round | 27/02/2022 | UE Engordany | - | UE Sant Julià | 1:3 | |
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| 18. Round | 06/03/2022 | Inter Club d'Escaldes | - | UE Engordany | 4:1 |
Uruguay