| 1. Round | 12/02/2000 | Instituto de Córdoba | - | River Plate | 1:2 | ||||
| 2. Round | 17/02/2000 | River Plate | - | Rosario Central | 1:1 | ||||
| 3. Round | 26/02/2000 | Colón de Santa Fe | - | River Plate | 1:4 | ||||
| 4. Round | 04/03/2000 | River Plate | - | Estudiantes | 2:2 |  |
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| 6. Round | 18/03/2000 | River Plate | - | Independiente | 2:0 | ||||
| 12. Round | 19/05/2000 | Newell's Old Boys | - | River Plate | 2:4 |  |
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| 13. Round | 27/05/2000 | River Plate | - | Unión de Santa Fe | 1:2 | ||||
| 14. Round | 10/06/2000 | Gimnasia de La Plata | - | River Plate | 0:4 | ||||
| 15. Round | 17/06/2000 | River Plate | - | Talleres de Córdoba | 2:0 | |
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| 17. Round | 01/07/2000 | River Plate | - | Chacarita Juniors | 5:0 | ||||
| 18. Round | 08/07/2000 | Ferro Carril Oeste | - | River Plate | 0:3 | ||||
| 19. Round | 14/07/2000 | River Plate | - | San Lorenzo | 2:2 |
Colombia