| 1. Round | 29/07/2000 | Estudiantes | - | River Plate | 1:1 | ||||
| 2. Round | 05/08/2000 | River Plate | - | Vélez Sarsfield | 2:1 | ||||
| 3. Round | 18/08/2000 | Colón de Santa Fe | - | River Plate | 1:2 | ||||
| 4. Round | 26/08/2000 | River Plate | - | Rosario Central | 4:1 | ||||
| 5. Round | 05/09/2000 | Independiente | - | River Plate | 0:1 | ||||
| 6. Round | 09/09/2000 | River Plate | - | Talleres de Córdoba | 4:1 | ||||
| 7. Round | 16/09/2000 | CA Los Andes | - | River Plate | 0:4 |  |
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| 8. Round | 23/09/2000 | River Plate | - | San Lorenzo | 2:2 | ||||
| 9. Round | 30/09/2000 | Chacarita Juniors | - | River Plate | 1:0 | ||||
| 10. Round | 14/10/2000 | River Plate | - | Boca Juniors | 1:1 | ||||
| 11. Round | 21/10/2000 | Argentinos Juniors | - | River Plate | 2:2 | |
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| 12. Round | 26/10/2000 | River Plate | - | Unión de Santa Fe | 1:1 | |
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| 13. Round | 04/11/2000 | Gimnasia de La Plata | - | River Plate | 2:2 | |
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| 15. Round | 18/11/2000 | Racing Club | - | River Plate | 0:1 | ||||
| 16. Round | 25/11/2000 | River Plate | - | Belgrano de Córdoba | 4:2 | ||||
| 17. Round | 02/12/2000 | Almagro | - | River Plate | 4:5 | |
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| 18. Round | 09/12/2000 | River Plate | - | Huracán | 1:1 | ||||
| 19. Round | 16/12/2000 | Lanús | - | River Plate | 3:2 | |
Colombia