| 1. Round | 04/03/2022 | Doxa Katokopias | - | Olympiakos Nikosia | 1:1 | ||||
| 2. Round | 11/03/2022 | Olympiakos Nikosia | - | AEL Limassol | 0:1 |  |
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| 3. Round | 18/03/2022 | PAEEK | - | Olympiakos Nikosia | 0:1 | ||||
| 4. Round | 02/04/2022 | Ethnikos Achna | - | Olympiakos Nikosia | 1:0 | ||||
| 5. Round | 08/04/2022 | Olympiakos Nikosia | - | Omonia Nikosia | 3:0 | ||||
| 6. Round | 16/04/2022 | Olympiakos Nikosia | - | Doxa Katokopias | 1:0 |  |
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| 7. Round | 29/04/2022 | AEL Limassol | - | Olympiakos Nikosia | 0:4 | ||||
| 8. Round | 06/05/2022 | Olympiakos Nikosia | - | PAEEK | 4:3 | ||||
| 9. Round | 16/05/2022 | Olympiakos Nikosia | - | Ethnikos Achna | 1:1 | ||||
| 10. Round | 20/05/2022 | Omonia Nikosia | - | Olympiakos Nikosia | 1:1 |
Cyprus