| 1. Round | 18/09/2008 | Sampdoria | - | FBK Kaunas | 5:0 | ||||
| 1. Round | 02/10/2008 | FBK Kaunas | - | Sampdoria | 1:2 | ||||
| Group C | 23/10/2008 | Partizan | - | Sampdoria | 1:2 | ||||
| Group C | 27/11/2008 | Sampdoria | - | VfB Stuttgart | 1:1 | ||||
| Group C | 03/12/2008 | Standard Liège | - | Sampdoria | 3:0 | ||||
| Group C | 18/12/2008 | Sampdoria | - | Sevilla FC | 1:0 | ||||
| 3. Round | 18/02/2009 | Sampdoria | - | Metalist Kharkiv | 0:1 |  |
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| 3. Round | 26/02/2009 | Metalist Kharkiv | - | Sampdoria | 2:0 |
Lithuania