| 1. Round | 07/08/2021 | Luton Town | - | Peterborough United | 3:0 |  |
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| 2. Round | 14/08/2021 | Peterborough United | - | Derby County | 2:1 | |
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| 3. Round | 17/08/2021 | Peterborough United | - | Cardiff City | 2:2 | ||||
| 12. Round | 16/10/2021 | Middlesbrough FC | - | Peterborough United | 2:0 | ||||
| 13. Round | 20/10/2021 | Hull City | - | Peterborough United | 1:2 | ||||
| 14. Round | 23/10/2021 | Peterborough United | - | Queens Park Rangers | 2:1 | ||||
| 15. Round | 30/10/2021 | Swansea City | - | Peterborough United | 3:0 | ||||
| 16. Round | 02/11/2021 | Peterborough United | - | Huddersfield Town | 1:1 | ||||
| 17. Round | 06/11/2021 | Peterborough United | - | Fulham FC | 0:1 | ||||
| 18. Round | 20/11/2021 | Stoke City | - | Peterborough United | 2:0 | ||||
| 19. Round | 24/11/2021 | Blackburn Rovers | - | Peterborough United | 4:0 | |
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| 28. Round | 22/01/2022 | West Bromwich Albion | - | Peterborough United | 3:0 | ||||
| 25. Round | 25/01/2022 | Birmingham City | - | Peterborough United | 2:2 | ||||
| 36. Round | 04/03/2022 | Huddersfield Town | - | Peterborough United | 3:0 |
England