| 19. Round | 13/02/2021 | FK AP Brera Strumica | - | FK Rabotnički | 0:1 | ||||
| 20. Round | 28/02/2021 | KF Shkupi | - | FK AP Brera Strumica | 0:0 | ||||
| 21. Round | 03/03/2021 | FK AP Brera Strumica | - | Makedonija GP | 2:1 | ||||
| 22. Round | 07/03/2021 | FK Belasica | - | FK AP Brera Strumica | 0:0 | ||||
| 23. Round | 13/03/2021 | FK Rabotnički | - | FK AP Brera Strumica | 0:2 |  |
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| 24. Round | 20/03/2021 | FK AP Brera Strumica | - | FC Struga | 1:0 | ||||
| 25. Round | 03/04/2021 | Makedonija GP | - | FK AP Brera Strumica | 1:2 | ||||
| 26. Round | 11/04/2021 | FK AP Brera Strumica | - | KF Shkupi | 0:1 | ||||
| 27. Round | 14/04/2021 | KF Shkëndija 79 | - | FK AP Brera Strumica | 1:0 | ||||
| 28. Round | 18/04/2021 | FK AP Brera Strumica | - | Vardar Skopje | 3:0 | ||||
| 29. Round | 24/04/2021 | Sileks Kratovo | - | FK AP Brera Strumica | 3:2 | ||||
| 30. Round | 28/04/2021 | FK AP Brera Strumica | - | FK Renova | 1:1 | ||||
| 31. Round | 01/05/2021 | FK Pelister | - | FK AP Brera Strumica | 3:1 | ||||
| 32. Round | 09/05/2021 | FK Belasica | - | FK AP Brera Strumica | 0:2 | ||||
| 33. Round | 16/05/2021 | FK AP Brera Strumica | - | FK Borec | 3:1 |
North Macedonia