| 3. Round | 30/07/2021 | Lokomotiva Zagreb | - | Hrvatski Dragovoljac | 3:2 | ||||
| 5. Round | 14/08/2021 | Lokomotiva Zagreb | - | NK Istra 1961 | 4:0 | ||||
| 11. Round | 02/10/2021 | Lokomotiva Zagreb | - | Slaven Belupo | 3:0 | ||||
| 16. Round | 21/11/2021 | HNK Gorica | - | Lokomotiva Zagreb | 2:2 | ||||
| 17. Round | 26/11/2021 | NK Osijek | - | Lokomotiva Zagreb | 3:1 | ||||
| 20. Round | 17/12/2021 | Slaven Belupo | - | Lokomotiva Zagreb | 2:1 | ||||
| 24. Round | 20/02/2022 | Dinamo Zagreb | - | Lokomotiva Zagreb | 0:0 | ||||
| 25. Round | 26/02/2022 | Lokomotiva Zagreb | - | HNK Gorica | 2:0 | ||||
| 26. Round | 04/03/2022 | Lokomotiva Zagreb | - | NK Osijek | 0:0 | ||||
| 28. Round | 19/03/2022 | Hajduk Split | - | Lokomotiva Zagreb | 4:0 | ||||
| 32. Round | 23/04/2022 | NK Istra 1961 | - | Lokomotiva Zagreb | 2:2 | ||||
| 33. Round | 01/05/2022 | Lokomotiva Zagreb | - | Dinamo Zagreb | 1:1 | ||||
| 34. Round | 07/05/2022 | HNK Gorica | - | Lokomotiva Zagreb | 3:3 | ||||
| 35. Round | 15/05/2022 | NK Osijek | - | Lokomotiva Zagreb | 1:0 |  |
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| 36. Round | 20/05/2022 | Lokomotiva Zagreb | - | HNK Šibenik | 2:1 |
Croatia