| 2. Round | 09/08/2020 | Chinandega | - | Real Estelí FC | 1:5 | ||||
| 3. Round | 13/08/2020 | Managua FC | - | Chinandega | 1:0 | ||||
| 9. Round | 20/09/2020 | Chinandega | - | CD Walter Ferretti | 2:2 | ||||
| 10. Round | 27/09/2020 | Chinandega | - | Diriangén FC | 1:3 | ||||
| 11. Round | 01/10/2020 | Real Estelí FC | - | Chinandega | 3:0 | ||||
| 13. Round | 26/10/2020 | Club Deportivo Ocotal | - | Chinandega | 1:2 |  |
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| 14. Round | 28/10/2020 | Junior Managua | - | Chinandega | 0:1 | |
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| 15. Round | 01/11/2020 | Chinandega | - | Real Madriz | 1:1 | ||||
| 12. Round | 11/11/2020 | Chinandega | - | Managua FC | 0:0 |  |
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| 17. Round | 15/11/2020 | Chinandega | - | ART Municipal Jalapa | 1:1 | ||||
| 18. Round | 20/11/2020 | CD Walter Ferretti | - | Chinandega | 4:0 |
Colombia