| 1. Round | 16/08/2021 | Sunderland AFC U23 | - | Fulham FC U23 | 3:4 | ||||
| 2. Round | 20/08/2021 | Fulham FC U23 | - | West Bromwich Albion U23 | 3:0 | ||||
| 3. Round | 27/08/2021 | Aston Villa U23 | - | Fulham FC U23 | 1:1 | ||||
| 4. Round | 10/09/2021 | Fulham FC U23 | - | Southampton FC U23 | 3:0 | ||||
| 6. Round | 24/09/2021 | Fulham FC U23 | - | Newcastle United U23 | 3:1 | ||||
| 7. Round | 01/10/2021 | Norwich City U23 | - | Fulham FC U23 | 0:2 | ||||
| 9. Round | 22/10/2021 | Fulham FC U23 | - | Nottingham Forest U23 | 2:1 | ||||
| 10. Round | 01/11/2021 | Fulham FC U23 | - | Middlesbrough FC U23 | 2:0 | ||||
| 11. Round | 08/11/2021 | Burnley FC U23 | - | Fulham FC U23 | 1:2 | ||||
| 12. Round | 19/11/2021 | Fulham FC U23 | - | Stoke City U23 | 3:0 | ||||
| 14. Round | 03/12/2021 | Fulham FC U23 | - | Wolverhampton Wanderers U23 | 4:2 |
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