| 1. Round | 31/07/2022 | Motagua | - | Honduras Progreso | 4:0 | ||||
| 2. Round | 08/08/2022 | Real España | - | Motagua | 1:1 | ||||
| 3. Round | 11/08/2022 | Motagua | - | Vida | 2:2 | ||||
| 5. Round | 21/08/2022 | Lobos UPNFM | - | Motagua | 2:3 | ||||
| 6. Round | 28/08/2022 | Olancho FC | - | Motagua | 0:1 | ||||
| 8. Round | 04/09/2022 | Real Sociedad | - | Motagua | 1:2 | ||||
| 9. Round | 11/09/2022 | Motagua | - | Victoria | 2:1 | ||||
| 10. Round | 18/09/2022 | Honduras Progreso | - | Motagua | 0:1 |  |
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| 11. Round | 02/10/2022 | Motagua | - | Real España | 1:2 | ||||
| 12. Round | 09/10/2022 | Vida | - | Motagua | 0:3 | ||||
| 13. Round | 15/10/2022 | Marathón | - | Motagua | 2:2 | |
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| 17. Round | 13/11/2022 | Motagua | - | Real Sociedad | 2:2 | ||||
| 18. Round | 19/11/2022 | Victoria | - | Motagua | 1:0 |
Honduras