| 9. Round | 12/09/2021 | Nueva Concepción | - | Xelaju MC | 2:0 | ||||
| 10. Round | 19/09/2021 | Sololá FC | - | Nueva Concepción | 3:0 | ||||
| 11. Round | 26/09/2021 | Nueva Concepción | - | Deportivo Malacateco | 0:0 |  |
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| 12. Round | 03/10/2021 | Achuapa | - | Nueva Concepción | 1:0 | |
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| 17. Round | 31/10/2021 | Nueva Concepción | - | Santa Lucía | 1:1 | ||||
| 18. Round | 06/11/2021 | CSD Municipal | - | Nueva Concepción | 2:0 |
Guatemala