| 3. Round | 30/01/2022 | Xelaju MC | - | Nueva Concepción | 2:1 | ||||
| 4. Round | 03/02/2022 | Antigua GFC | - | Nueva Concepción | 4:0 | ||||
| 6. Round | 09/02/2022 | Iztapa | - | Nueva Concepción | 2:1 |  |
|||
| 7. Round | 13/02/2022 | Nueva Concepción | - | CSD Municipal | 1:0 | ||||
| 8. Round | 20/02/2022 | Achuapa | - | Nueva Concepción | 1:1 | ||||
| 10. Round | 02/03/2022 | Deportivo Guastatoya | - | Nueva Concepción | 4:1 | ||||
| 18. Round | 20/04/2022 | CSD Municipal | - | Nueva Concepción | 2:0 | ||||
| 19. Round | 24/04/2022 | Nueva Concepción | - | Achuapa | 1:1 | ||||
| 20. Round | 30/04/2022 | Santa Lucía | - | Nueva Concepción | 8:1 | ||||
| 21. Round | 04/05/2022 | Nueva Concepción | - | Deportivo Guastatoya | 2:3 |
Guatemala