| Group 3 | 10/03/2021 | Jocoro FC | - | CD Águila | 0:1 | ||||
| Group B | 24/04/2021 | CD Águila | - | Municipal Limeño | 1:1 | ||||
| Group B | 28/04/2021 | Santa Tecla FC | - | CD Águila | 1:1 | ||||
| Group B | 01/05/2021 | CD Águila | - | AD Chalatenango | 2:1 | ||||
| Quarter-finals | 05/05/2021 | CD Águila | - | Alianza | 0:1 | ||||
| Quarter-finals | 09/05/2021 | Alianza | - | CD Águila | 2:1 |
El Salvador