| 2. Round | 12/09/2020 | Kolos Kovalivka | - | FK Lviv | 4:0 |  |
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| 3. Round | 19/09/2020 | Dinamo Kiev | - | FK Lviv | 3:1 |  |
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| 5. Round | 03/10/2020 | Rukh Lviv | - | FK Lviv | 0:0 | ||||
| 6. Round | 17/10/2020 | Shakhtar Donetsk | - | FK Lviv | 5:1 | ||||
| 7. Round | 24/10/2020 | FK Lviv | - | SK Dnipro-1 | 1:3 | ||||
| 8. Round | 01/11/2020 | FK Lviv | - | Vorskla Poltava | 1:0 | |
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| 9. Round | 07/11/2020 | FK Oleksandriya | - | FK Lviv | 1:0 | ||||
| 10. Round | 22/11/2020 | Desna Chernigov | - | FK Lviv | 0:1 | ||||
| 11. Round | 27/11/2020 | FK Lviv | - | FK Mariupol | 1:3 |  |
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| 12. Round | 05/12/2020 | FK Lviv | - | Inhulets Petrove | 1:1 | |
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| 14. Round | 13/02/2021 | FC Mynai | - | FK Lviv | 1:2 | ||||
| 15. Round | 20/02/2021 | FK Lviv | - | Kolos Kovalivka | 0:2 | ||||
| 16. Round | 28/02/2021 | FK Lviv | - | Dinamo Kiev | 1:4 | ||||
| 17. Round | 07/03/2021 | Zorya Lugansk | - | FK Lviv | 4:0 | |
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| 23. Round | 24/04/2021 | FK Lviv | - | Desna Chernigov | 1:0 | ||||
| 18. Round | 28/04/2021 | FK Lviv | - | Rukh Lviv | 1:1 | |
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| 25. Round | 06/05/2021 | Inhulets Petrove | - | FK Lviv | 1:0 | |
France