| 5. Round | 20/08/2021 | Zlaté Moravce | - | FK Pohronie | 1:0 | ||||
| 6. Round | 27/08/2021 | FK Pohronie | - | FC DAC 1904 | 0:3 | ||||
| 7. Round | 11/09/2021 | FK Senica | - | FK Pohronie | 1:0 | ||||
| 8. Round | 18/09/2021 | Tatran Liptovský Mikuláš | - | FK Pohronie | 5:1 | ||||
| 9. Round | 24/09/2021 | FK Pohronie | - | AS Trenčín | 2:2 | ||||
| 10. Round | 03/10/2021 | Slovan Bratislava | - | FK Pohronie | 5:1 | ||||
| 11. Round | 16/10/2021 | FK Pohronie | - | MFK Ružomberok | 2:2 | ||||
| 12. Round | 23/10/2021 | FK Pohronie | - | Spartak Trnava | 0:2 | ||||
| 13. Round | 30/10/2021 | MFK Zemplín Michalovce | - | FK Pohronie | 0:2 | ||||
| 14. Round | 06/11/2021 | FK Pohronie | - | MŠK Žilina | 1:2 | ||||
| 15. Round | 20/11/2021 | ŠKF Sereď | - | FK Pohronie | 3:1 | ||||
| 16. Round | 27/11/2021 | FK Pohronie | - | Zlaté Moravce | 0:2 | ||||
| 17. Round | 04/12/2021 | FC DAC 1904 | - | FK Pohronie | 2:0 | ||||
| 18. Round | 11/12/2021 | FK Pohronie | - | FK Senica | 0:1 |
Slovakia