| 1. Round | 24/07/2021 | Levski Sofia | - | Slavia Sofia | 1:2 | ||||
| 3. Round | 07/08/2021 | Botev Plovdiv | - | Slavia Sofia | 1:0 | ||||
| 4. Round | 14/08/2021 | Slavia Sofia | - | PFC Beroe | 3:2 | ||||
| 5. Round | 22/08/2021 | Lokomotiv Plovdiv | - | Slavia Sofia | 0:1 | ||||
| 6. Round | 27/08/2021 | Slavia Sofia | - | CSKA 1948 Sofia | 2:1 | ||||
| 7. Round | 11/09/2021 | CSKA Sofia | - | Slavia Sofia | 1:1 |  |
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| 8. Round | 19/09/2021 | Slavia Sofia | - | PFC Ludogorets Razgrad | 1:0 |  |
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| 10. Round | 02/10/2021 | Slavia Sofia | - | Pirin Blagoevgrad | 1:1 | ||||
| 11. Round | 17/10/2021 | Cherno More Varna | - | Slavia Sofia | 1:1 | ||||
| 12. Round | 23/10/2021 | Arda Kardzhali | - | Slavia Sofia | 1:1 | ||||
| 14. Round | 06/11/2021 | Slavia Sofia | - | Levski Sofia | 0:1 | ||||
| 15. Round | 20/11/2021 | Tsarsko Selo Sofia | - | Slavia Sofia | 2:5 | ||||
| 16. Round | 26/11/2021 | Slavia Sofia | - | Botev Plovdiv | 0:0 | ||||
| 18. Round | 05/12/2021 | Slavia Sofia | - | Lokomotiv Plovdiv | 1:1 | ||||
| 20. Round | 20/02/2022 | Slavia Sofia | - | CSKA Sofia | 2:3 | |
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| 21. Round | 26/02/2022 | PFC Ludogorets Razgrad | - | Slavia Sofia | 3:1 | ||||
| 22. Round | 07/03/2022 | Slavia Sofia | - | Lokomotiv Sofia | 3:0 | ||||
| 26. Round | 08/04/2022 | Botev Vratsa | - | Slavia Sofia | 2:1 |
Bulgaria