| 1. Round | 06/02/2016 | Patronato de Paraná | - | San Lorenzo | 2:2 | ||||
| 2. Round | 13/02/2016 | San Lorenzo | - | Sarmiento de Junín | 2:1 | ||||
| 3. Round | 16/02/2016 | Olimpo de Bahía Blanca | - | San Lorenzo | 0:2 | ||||
| 5. Round | 27/02/2016 | Huracán | - | San Lorenzo | 1:1 | ||||
| 6. Round | 05/03/2016 | Gimnasia de La Plata | - | San Lorenzo | 0:0 | ||||
| 7. Round | 12/03/2016 | San Lorenzo | - | Arsenal de Sarandí | 0:2 | ||||
| 8. Round | 20/03/2016 | Quilmes | - | San Lorenzo | 3:0 | ||||
| 10. Round | 09/04/2016 | Godoy Cruz | - | San Lorenzo | 0:1 |  |
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| 11. Round | 17/04/2016 | San Lorenzo | - | Rosario Central | 2:1 | ||||
| 12. Round | 23/04/2016 | San Lorenzo | - | Huracán | 1:0 | ||||
| 13. Round | 30/04/2016 | Independiente | - | San Lorenzo | 0:1 | ||||
| 14. Round | 07/05/2016 | San Lorenzo | - | River Plate | 2:1 |  |
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| 15. Round | 14/05/2016 | Colón de Santa Fe | - | San Lorenzo | 0:2 | |
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| 16. Round | 22/05/2016 | San Lorenzo | - | Banfield | 1:1 |
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