| Group 6 | 02/08/2018 | Atlético Zacatepec | - | Cruz Azul | 2:3 |  |
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| Group 6 | 09/08/2018 | Cruz Azul | - | Atlas Guadalajara | 2:2 | ||||
| Group 6 | 16/08/2018 | Cruz Azul | - | Atlético Zacatepec | 2:0 | |
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| Group 6 | 30/08/2018 | Atlas Guadalajara | - | Cruz Azul | 1:0 | ||||
| Round of 16 | 26/09/2018 | Club Tijuana | - | Cruz Azul | 1:2 | |
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| Quarter-finals | 03/10/2018 | Cruz Azul | - | FC Juárez | 2:0 | |
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| Semi-finals | 25/10/2018 | Cruz Azul | - | Club León | 5:4 pso | ||||
| Final | 01/11/2018 | CF Monterrey | - | Cruz Azul | 0:2 | |
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