| 1. Round | 23/07/2021 | PFC Beroe | - | Lokomotiv Sofia | 1:0 |  |
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| 4. Round | 14/08/2021 | Slavia Sofia | - | PFC Beroe | 3:2 | ||||
| 5. Round | 23/08/2021 | PFC Beroe | - | Botev Vratsa | 1:0 | |
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| 6. Round | 28/08/2021 | Levski Sofia | - | PFC Beroe | 2:1 | ||||
| 7. Round | 13/09/2021 | PFC Beroe | - | Tsarsko Selo Sofia | 1:0 | |
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| 9. Round | 24/09/2021 | PFC Beroe | - | Arda Kardzhali | 1:1 | ||||
| 10. Round | 01/10/2021 | PFC Beroe | - | Lokomotiv Plovdiv | 1:0 | ||||
| 12. Round | 24/10/2021 | PFC Beroe | - | CSKA Sofia | 0:0 | ||||
| 14. Round | 05/11/2021 | Lokomotiv Sofia | - | PFC Beroe | 0:3 | |
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| 15. Round | 19/11/2021 | PFC Beroe | - | Pirin Blagoevgrad | 1:1 | ||||
| 16. Round | 26/11/2021 | Cherno More Varna | - | PFC Beroe | 1:0 | ||||
| 17. Round | 30/11/2021 | PFC Beroe | - | Slavia Sofia | 2:1 | |
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| 18. Round | 04/12/2021 | Botev Vratsa | - | PFC Beroe | 1:0 | ||||
| 19. Round | 12/12/2021 | PFC Beroe | - | Levski Sofia | 1:1 |
Bulgaria