| 2. Round | 01/08/2021 | Lokomotiv Sofia | - | Lokomotiv Plovdiv | 1:0 | ||||
| 7. Round | 12/09/2021 | Lokomotiv Plovdiv | - | Levski Sofia | 2:2 | ||||
| 3. Round | 19/10/2021 | Lokomotiv Plovdiv | - | Pirin Blagoevgrad | 2:1 | ||||
| 13. Round | 31/10/2021 | CSKA Sofia | - | Lokomotiv Plovdiv | 1:3 | ||||
| 14. Round | 07/11/2021 | PFC Ludogorets Razgrad | - | Lokomotiv Plovdiv | 1:0 |  |
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| 16. Round | 27/11/2021 | Pirin Blagoevgrad | - | Lokomotiv Plovdiv | 2:3 | ||||
| 17. Round | 01/12/2021 | Lokomotiv Plovdiv | - | Cherno More Varna | 1:1 | ||||
| 18. Round | 05/12/2021 | Slavia Sofia | - | Lokomotiv Plovdiv | 1:1 |  |
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| 19. Round | 10/12/2021 | Lokomotiv Plovdiv | - | Botev Vratsa | 2:4 | ||||
| 20. Round | 19/02/2022 | Levski Sofia | - | Lokomotiv Plovdiv | 2:1 |  |
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| 22. Round | 05/03/2022 | Botev Plovdiv | - | Lokomotiv Plovdiv | 2:1 | ||||
| 23. Round | 13/03/2022 | Lokomotiv Plovdiv | - | PFC Beroe | 2:0 | ||||
| 24. Round | 18/03/2022 | Arda Kardzhali | - | Lokomotiv Plovdiv | 5:1 | ||||
| 25. Round | 03/04/2022 | CSKA 1948 Sofia | - | Lokomotiv Plovdiv | 4:0 |
Bulgaria