| 2. Round | 17/07/2022 | Club Deportivo Ocotal | - | Real Estelí FC | 0:1 | ||||
| 3. Round | 24/07/2022 | H&H Export Sébaco | - | Real Estelí FC | 0:0 | ||||
| 5. Round | 08/08/2022 | Juventus Managua | - | Real Estelí FC | 0:0 |  |
|||
| 6. Round | 12/08/2022 | Managua FC | - | Real Estelí FC | 3:0 | |
|||
| 8. Round | 21/08/2022 | Real Estelí FC | - | UNAN Managua | 1:0 | ||||
| 4. Round | 25/08/2022 | Real Estelí FC | - | CD Walter Ferretti | 2:0 | ||||
| 9. Round | 28/08/2022 | Matagalpa FC | - | Real Estelí FC | 0:3 | |
|||
| 7. Round | 02/09/2022 | Real Estelí FC | - | Diriangén FC | 1:0 | ||||
| 10. Round | 05/09/2022 | ART Municipal Jalapa | - | Real Estelí FC | 0:0 | ||||
| 11. Round | 11/09/2022 | Real Estelí FC | - | Club Deportivo Ocotal | 5:0 | ||||
| 12. Round | 03/10/2022 | Real Estelí FC | - | H&H Export Sébaco | 3:1 |  |
|||
| 13. Round | 24/10/2022 | CD Walter Ferretti | - | Real Estelí FC | 2:1 | |
|||
| 15. Round | 30/10/2022 | Real Estelí FC | - | Managua FC | 2:2 | |
|||
| 17. Round | 28/11/2022 | UNAN Managua | - | Real Estelí FC | 1:4 | ||||
| 18. Round | 02/12/2022 | Real Estelí FC | - | Matagalpa FC | 6:0 | |
Nicaragua