1. Round | 01/08/2021 | Alianza | - | Municipal Limeño | 4:1 | ||||
2. Round | 08/08/2021 | Platense Zacatecoluca | - | Alianza | 2:2 | ||||
3. Round | 11/08/2021 | AD Chalatenango | - | Alianza | 2:1 | ||||
4. Round | 15/08/2021 | Alianza | - | Luis Ángel Firpo | 2:2 | ||||
6. Round | 26/08/2021 | Alianza | - | FAS | 1:0 | ||||
8. Round | 12/09/2021 | Alianza | - | Atlético Marte | 3:1 | ||||
9. Round | 16/09/2021 | Santa Tecla FC | - | Alianza | 0:4 | ||||
10. Round | 19/09/2021 | Alianza | - | CD Águila | 2:1 | ||||
11. Round | 25/09/2021 | Jocoro FC | - | Alianza | 3:3 | ||||
12. Round | 02/10/2021 | Municipal Limeño | - | Alianza | 0:3 | ||||
14. Round | 21/10/2021 | Alianza | - | AD Chalatenango | 1:0 | ||||
15. Round | 24/10/2021 | Luis Ángel Firpo | - | Alianza | 2:1 | ||||
16. Round | 30/10/2021 | Once Municipal | - | Alianza | 2:3 | ||||
21. Round | 21/11/2021 | CD Águila | - | Alianza | 0:1 | ||||
22. Round | 27/11/2021 | Alianza | - | Jocoro FC | 2:0 |