| 2. Round | 08/08/2021 | Jocoro FC | - | Once Municipal | 3:4 | ||||
| 3. Round | 11/08/2021 | Once Municipal | - | Municipal Limeño | 4:1 | ||||
| 4. Round | 15/08/2021 | Platense Zacatecoluca | - | Once Municipal | 1:1 | ||||
| 5. Round | 10/09/2021 | Alianza | - | Once Municipal | 1:0 | ||||
| 8. Round | 12/09/2021 | Once Municipal | - | FAS | 1:3 | ||||
| 13. Round | 17/10/2021 | Once Municipal | - | Jocoro FC | 2:2 | ||||
| 15. Round | 24/10/2021 | Once Municipal | - | Platense Zacatecoluca | 1:1 | ||||
| 16. Round | 30/10/2021 | Once Municipal | - | Alianza | 2:3 | ||||
| 18. Round | 07/11/2021 | Once Municipal | - | AD Chalatenango | 1:2 |  |
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| 19. Round | 14/11/2021 | FAS | - | Once Municipal | 3:2 | ||||
| 21. Round | 21/11/2021 | Atlético Marte | - | Once Municipal | 1:4 | ||||
| 22. Round | 27/11/2021 | Once Municipal | - | Santa Tecla FC | 4:3 |
El Salvador