1. Round | 02/08/2021 | ART Municipal Jalapa | - | Club Deportivo Ocotal | 1:1 | ||||
7. Round | 13/09/2021 | Juventus Managua | - | Club Deportivo Ocotal | 3:1 | ||||
13. Round | 22/10/2021 | Diriangén FC | - | Club Deportivo Ocotal | 3:0 | ||||
18. Round | 22/11/2021 | Real Estelí FC | - | Club Deportivo Ocotal | 4:0 |