| 1. Round | 26/10/2021 | Zamalek | - | ENPPI | 2:0 |  |
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| 2. Round | 30/10/2021 | ENPPI | - | Al Mokawloon | 3:2 | ||||
| 3. Round | 05/11/2021 | Ghazl Al Mehalla | - | ENPPI | 3:0 | ||||
| 4. Round | 19/11/2021 | ENPPI | - | Smouha Sporting Club | 1:1 | ||||
| 5. Round | 23/11/2021 | Future FC | - | ENPPI | 1:2 | ||||
| 7. Round | 20/12/2021 | El Gouna | - | ENPPI | 1:1 | ||||
| 6. Round | 25/12/2021 | ENPPI | - | Pyramids FC | 1:1 | ||||
| 8. Round | 09/02/2022 | ENPPI | - | Misr lel-Maqasah SC | 0:0 | ||||
| 9. Round | 16/02/2022 | Pharco FC | - | ENPPI | 1:0 | ||||
| 10. Round | 22/02/2022 | ENPPI | - | Ittihad El Iskandary | 1:0 | ||||
| 11. Round | 03/03/2022 | Al Masry Club | - | ENPPI | 2:2 | ||||
| 12. Round | 08/03/2022 | ENPPI | - | El Sharkia Lel Dokhan | 1:2 |
Egypt