| 5. Round | 22/08/2021 | FAS | - | Platense Zacatecoluca | 0:1 |  |
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| 6. Round | 26/08/2021 | Alianza | - | FAS | 1:0 | ||||
| 8. Round | 12/09/2021 | Once Municipal | - | FAS | 1:3 | ||||
| 10. Round | 19/09/2021 | FAS | - | Isidro Metapán | 3:0 | ||||
| 14. Round | 20/10/2021 | Jocoro FC | - | FAS | 0:0 | ||||
| 17. Round | 02/11/2021 | FAS | - | Alianza | 0:1 | ||||
| 19. Round | 14/11/2021 | FAS | - | Once Municipal | 3:2 | ||||
| 20. Round | 17/11/2021 | FAS | - | AD Chalatenango | 1:1 |
Argentina