| 1. Round | 22/01/2022 | Once Caldas | - | Unión Magdalena | 1:1 | ||||
| 2. Round | 27/01/2022 | Unión Magdalena | - | Alianza Petrolera | 0:0 | ||||
| 5. Round | 06/02/2022 | Millonarios | - | Unión Magdalena | 1:0 | ||||
| 6. Round | 11/02/2022 | Unión Magdalena | - | Envigado FC | 2:1 |  |
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| 8. Round | 20/02/2022 | Atlético Nacional | - | Unión Magdalena | 1:0 | ||||
| 11. Round | 18/03/2022 | Unión Magdalena | - | Cortuluá | 0:2 |
Colombia