| 1. Round | 16/08/2020 | Hajduk Split | - | NK Istra 1961 | 2:0 | ||||
| 2. Round | 21/08/2020 | NK Istra 1961 | - | Dinamo Zagreb | 0:1 | ||||
| 4. Round | 13/09/2020 | NK Istra 1961 | - | NK Varaždin | 0:1 | ||||
| 5. Round | 19/09/2020 | HNK Gorica | - | NK Istra 1961 | 2:2 | ||||
| 6. Round | 26/09/2020 | NK Istra 1961 | - | HNK Šibenik | 1:0 | ||||
| 7. Round | 02/10/2020 | Lokomotiva Zagreb | - | NK Istra 1961 | 0:0 | ||||
| 8. Round | 16/10/2020 | Slaven Belupo | - | NK Istra 1961 | 5:1 | ||||
| 10. Round | 31/10/2020 | NK Istra 1961 | - | Hajduk Split | 1:0 | ||||
| 11. Round | 08/11/2020 | Dinamo Zagreb | - | NK Istra 1961 | 5:0 | ||||
| 9. Round | 25/11/2020 | NK Istra 1961 | - | NK Osijek | 1:4 | ||||
| 13. Round | 28/11/2020 | NK Varaždin | - | NK Istra 1961 | 1:1 | ||||
| 14. Round | 19/01/2021 | NK Istra 1961 | - | HNK Gorica | 1:1 | ||||
| 19. Round | 03/02/2021 | Hajduk Split | - | NK Istra 1961 | 1:0 | ||||
| 20. Round | 07/02/2021 | NK Istra 1961 | - | Dinamo Zagreb | 0:1 | ||||
| 21. Round | 14/02/2021 | HNK Rijeka | - | NK Istra 1961 | 1:1 | ||||
| 26. Round | 20/03/2021 | Slaven Belupo | - | NK Istra 1961 | 1:1 | ||||
| 27. Round | 03/04/2021 | NK Istra 1961 | - | NK Osijek | 0:2 |
Croatia