| 2. Round | 23/07/2021 | Rosario Central II | - | Vélez Sarsfield II | 3:0 | ||||
| 3. Round | 27/07/2021 | Gimnasia de La Plata II | - | Rosario Central II | 4:3 | ||||
| 7. Round | 20/08/2021 | Newell's Old Boys II | - | Rosario Central II | 1:1 | ||||
| 8. Round | 24/08/2021 | Rosario Central II | - | Arsenal de Sarandí II | 4:0 |  |
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| 9. Round | 30/08/2021 | Central Córdoba SdE II | - | Rosario Central II | 0:1 | ||||
| 10. Round | 03/09/2021 | Rosario Central II | - | Boca Juniors II | 1:3 | ||||
| 11. Round | 14/09/2021 | Banfield II | - | Rosario Central II | 1:3 | ||||
| 12. Round | 17/09/2021 | Rosario Central II | - | San Lorenzo II | 1:2 | ||||
| 13. Round | 24/09/2021 | Talleres de Córdoba II | - | Rosario Central II | 3:1 | ||||
| 14. Round | 01/10/2021 | Rosario Central II | - | Argentinos Juniors II | 0:2 | ||||
| 15. Round | 08/10/2021 | Estudiantes II | - | Rosario Central II | 1:1 | ||||
| 16. Round | 13/10/2021 | Rosario Central II | - | Patronato de Paraná II | 2:1 | ||||
| 17. Round | 18/10/2021 | Platense II | - | Rosario Central II | 0:3 | |
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| 18. Round | 24/10/2021 | Rosario Central II | - | Racing Club II | 1:2 | ||||
| 19. Round | 29/10/2021 | Unión de Santa Fe II | - | Rosario Central II | 0:0 |
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