| 1. Round | 15/08/2021 | Liverpool FC U23 | - | Manchester City U23 | 0:0 | ||||
| 4. Round | 11/09/2021 | Tottenham Hotspur U23 | - | Liverpool FC U23 | 2:1 | ||||
| 5. Round | 19/09/2021 | Liverpool FC U23 | - | Leeds United U23 | 0:4 | ||||
| 6. Round | 24/09/2021 | Chelsea FC U23 | - | Liverpool FC U23 | 4:3 |  |
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| 7. Round | 02/10/2021 | Manchester United U23 | - | Liverpool FC U23 | 3:0 | ||||
| 8. Round | 16/10/2021 | Liverpool FC U23 | - | Arsenal FC U23 | 3:0 | |
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| 11. Round | 06/11/2021 | West Ham United U23 | - | Liverpool FC U23 | 3:0 | ||||
| 12. Round | 20/11/2021 | Liverpool FC U23 | - | Crystal Palace U23 | 0:3 | ||||
| 14. Round | 03/12/2021 | Brighton & Hove Albion U23 | - | Liverpool FC U23 | 3:0 | ||||
| 17. Round | 15/01/2022 | Liverpool FC U23 | - | Everton FC U23 | 1:1 | ||||
| 22. Round | 12/03/2022 | Liverpool FC U23 | - | Tottenham Hotspur U23 | 7:1 | ||||
| 15. Round | 17/04/2022 | Liverpool FC U23 | - | West Ham United U23 | 3:0 |
Poland