| 1. Round | 14/08/2021 | RWD Molenbeek | - | Royal Excel Mouscron | 3:1 | ||||
| 2. Round | 21/08/2021 | Royal Excel Mouscron | - | Lommel SK | 0:1 | ||||
| 6. Round | 26/09/2021 | Royal Excel Mouscron | - | KVC Westerlo | 1:2 | ||||
| 8. Round | 17/10/2021 | Lommel SK | - | Royal Excel Mouscron | 3:0 | ||||
| 9. Round | 22/10/2021 | Royal Excel Mouscron | - | RWD Molenbeek | 1:1 | ||||
| 10. Round | 29/10/2021 | Excelsior Virton | - | Royal Excel Mouscron | 0:2 | ||||
| 11. Round | 06/11/2021 | Royal Excel Mouscron | - | SK Deinze | 2:0 | ||||
| 15. Round | 11/12/2021 | Royal Excel Mouscron | - | Lommel SK | 2:1 | ||||
| 16. Round | 18/12/2021 | SK Deinze | - | Royal Excel Mouscron | 2:2 | ||||
| 17. Round | 23/01/2022 | Royal Excel Mouscron | - | Lierse Kempenzonen | 0:0 | ||||
| 19. Round | 05/02/2022 | Royal Excel Mouscron | - | Waasland-Beveren | 3:0 | ||||
| 20. Round | 12/02/2022 | KVC Westerlo | - | Royal Excel Mouscron | 1:0 | ||||
| 21. Round | 20/02/2022 | Royal Excel Mouscron | - | Excelsior Virton | 2:1 | ||||
| 22. Round | 27/02/2022 | Lommel SK | - | Royal Excel Mouscron | 0:0 | ||||
| 27. Round | 08/04/2022 | Royal Excel Mouscron | - | KVC Westerlo | 2:6 | ||||
| 28. Round | 17/04/2022 | Waasland-Beveren | - | Royal Excel Mouscron | 2:0 |
France