| 5. Round | 21/08/2021 | RFC Seraing | - | Cercle Brugge | 2:1 | ||||
| 6. Round | 28/08/2021 | KAS Eupen | - | RFC Seraing | 1:2 | ||||
| 9. Round | 26/09/2021 | KRC Genk | - | RFC Seraing | 3:0 | ||||
| 12. Round | 22/10/2021 | RFC Seraing | - | Sporting Charleroi | 1:3 | ||||
| 22. Round | 18/01/2022 | RFC Seraing | - | Union Saint-Gilloise | 0:4 | ||||
| 23. Round | 22/01/2022 | Sint-Truidense VV | - | RFC Seraing | 3:1 | ||||
| 24. Round | 26/01/2022 | RFC Seraing | - | K Beerschot VA | 2:1 | ||||
| 25. Round | 29/01/2022 | RFC Seraing | - | KAS Eupen | 0:0 | ||||
| 26. Round | 04/02/2022 | Sporting Charleroi | - | RFC Seraing | 2:0 |  |
|||
| 27. Round | 11/02/2022 | RFC Seraing | - | Royal Antwerp FC | 0:1 | ||||
| 28. Round | 23/02/2022 | KAA Gent | - | RFC Seraing | 4:0 | ||||
| 29. Round | 27/02/2022 | SV Zulte Waregem | - | RFC Seraing | 1:0 | ||||
| 30. Round | 05/03/2022 | RFC Seraing | - | Club Brugge KV | 0:5 |  |
|||
| 33. Round | 02/04/2022 | KV Oostende | - | RFC Seraing | 2:2 | ||||
| 34. Round | 10/04/2022 | RFC Seraing | - | KRC Genk | 0:2 |
Belgium