| 1. Round | 25/07/2021 | Tigres FC | - | Bogotá FC | 0:0 | ||||
| 2. Round | 30/07/2021 | Atlético FC | - | Tigres FC | 2:1 | ||||
| 3. Round | 07/08/2021 | Tigres FC | - | Orsomarso SC | 1:2 | ||||
| 4. Round | 15/08/2021 | Valledupar FC | - | Tigres FC | 0:0 | ||||
| 5. Round | 23/08/2021 | Tigres FC | - | Boyacá Chicó | 0:1 |  |
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| 7. Round | 06/09/2021 | Tigres FC | - | Real Santander | 2:0 | ||||
| 8. Round | 10/09/2021 | Cortuluá | - | Tigres FC | 3:0 | ||||
| 12. Round | 12/10/2021 | Leones FC | - | Tigres FC | 2:0 | ||||
| 13. Round | 18/10/2021 | Tigres FC | - | Llaneros FC | 0:2 |
Colombia