| 1. Round | 03/06/2021 | Atenas | - | Rampla Juniors | 1:1 |  |
|||
| 2. Round | 10/06/2021 | Rampla Juniors | - | Racing | 2:2 | ||||
| 6. Round | 08/07/2021 | Rampla Juniors | - | Albion | 0:1 | |
|||
| 7. Round | 15/07/2021 | Rampla Juniors | - | Danubio | 0:0 | ||||
| 8. Round | 22/07/2021 | Rocha | - | Rampla Juniors | 2:0 | ||||
| 11. Round | 12/08/2021 | Rampla Juniors | - | Central Español | 2:1 | ||||
| 12. Round | 15/09/2021 | Rampla Juniors | - | Atenas | 2:1 | |
|||
| 13. Round | 22/09/2021 | Racing | - | Rampla Juniors | 2:0 | |
|||
| 14. Round | 29/09/2021 | Rampla Juniors | - | Villa Teresa | 0:0 | |
|||
| 16. Round | 12/10/2021 | Rampla Juniors | - | Uruguay Montevideo | 1:1 | ||||
| 17. Round | 19/10/2021 | Albion | - | Rampla Juniors | 2:0 | |
|||
| 18. Round | 27/10/2021 | Danubio | - | Rampla Juniors | 2:0 | |
|||
| 19. Round | 01/11/2021 | Rampla Juniors | - | Rocha | 2:1 | ||||
| 20. Round | 10/11/2021 | CA Cerro | - | Rampla Juniors | 1:2 | ||||
| 21. Round | 18/11/2021 | Rampla Juniors | - | Defensor Sporting | 0:5 | ||||
| 22. Round | 25/11/2021 | Central Español | - | Rampla Juniors | 3:0 |
Uruguay