| 14. Round | 18/01/2022 | Sliema Wanderers | - | Gżira United | 1:3 | ||||
| 15. Round | 22/01/2022 | Gudja United | - | Sliema Wanderers | 1:0 |  |
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| 12. Round | 26/01/2022 | Sliema Wanderers | - | Balzan FC | 1:0 | ||||
| 16. Round | 29/01/2022 | Sliema Wanderers | - | Sirens FC | 1:0 | ||||
| 17. Round | 05/02/2022 | Hibernians FC | - | Sliema Wanderers | 1:0 | ||||
| 18. Round | 13/02/2022 | Sliema Wanderers | - | St. Luċija FC | 1:1 | ||||
| 19. Round | 20/02/2022 | Mosta FC | - | Sliema Wanderers | 1:0 | ||||
| 20. Round | 26/02/2022 | Valletta FC | - | Sliema Wanderers | 1:0 | ||||
| 21. Round | 06/03/2022 | Sliema Wanderers | - | Birkirkara FC | 0:0 | ||||
| 22. Round | 11/03/2022 | Hamrun Spartans | - | Sliema Wanderers | 3:1 |
Italy