| 4. Round | 06/09/2000 | Sporting Lokeren | - | KV Mechelen | 3:2 | ||||
| 5. Round | 09/09/2000 | KV Mechelen | - | Standard Liège | 0:4 | ||||
| 6. Round | 16/09/2000 | RAA La Louviére | - | KV Mechelen | 2:2 | ||||
| 10. Round | 22/10/2000 | KV Mechelen | - | K.S.C. Eendracht Aalst | 4:1 |  |
|||
| 15. Round | 02/12/2000 | Royal Antwerp FC | - | KV Mechelen | 3:1 | ||||
| 21. Round | 03/02/2001 | KV Mechelen | - | Sporting Lokeren | 0:3 | ||||
| 22. Round | 11/02/2001 | Standard Liège | - | KV Mechelen | 2:0 | ||||
| 23. Round | 17/02/2001 | KV Mechelen | - | RAA La Louviére | 0:0 | |
|||
| 24. Round | 03/03/2001 | Germinal Beerschot | - | KV Mechelen | 4:1 | |
|||
| 26. Round | 18/03/2001 | KV Mechelen | - | KRC Harelbeke | 2:0 | ||||
| 27. Round | 01/04/2001 | K.S.C. Eendracht Aalst | - | KV Mechelen | 1:3 | ||||
| 28. Round | 07/04/2001 | KV Mechelen | - | Sint-Truidense VV | 1:2 | ||||
| 29. Round | 14/04/2001 | KVC Westerlo | - | KV Mechelen | 0:0 | ||||
| 33. Round | 12/05/2001 | RSC Anderlecht | - | KV Mechelen | 1:0 | ||||
| 34. Round | 20/05/2001 | KV Mechelen | - | Lierse SK (old) | 1:1 |
Belgium