| 2. Round | 25/09/2021 | AC Juvenes/Dogana | - | SP Tre Penne | 0:1 | ||||
| 3. Round | 03/10/2021 | SS Folgore/Falciano | - | AC Juvenes/Dogana | 2:1 | ||||
| 4. Round | 16/10/2021 | SS Pennarossa | - | AC Juvenes/Dogana | 0:0 | ||||
| 5. Round | 19/10/2021 | AC Juvenes/Dogana | - | FC Domagnano | 2:1 | ||||
| 7. Round | 31/10/2021 | SP La Fiorita | - | AC Juvenes/Dogana | 2:2 | ||||
| 9. Round | 21/11/2021 | SC Faetano | - | AC Juvenes/Dogana | 3:1 | ||||
| 10. Round | 28/11/2021 | AC Juvenes/Dogana | - | SS Virtus | 1:2 | ||||
| 18. Round | 29/01/2022 | AC Juvenes/Dogana | - | SS Folgore/Falciano | 0:4 | ||||
| 19. Round | 06/02/2022 | AC Juvenes/Dogana | - | SS Pennarossa | 0:2 | ||||
| 22. Round | 19/02/2022 | AC Juvenes/Dogana | - | SP La Fiorita | 0:4 | ||||
| 24. Round | 05/03/2022 | AC Juvenes/Dogana | - | SC Faetano | 1:2 | ||||
| 25. Round | 08/03/2022 | SS Virtus | - | AC Juvenes/Dogana | 0:0 | ||||
| 15. Round | 16/03/2022 | SP Tre Fiori | - | AC Juvenes/Dogana | 2:0 | ||||
| 27. Round | 20/03/2022 | AC Libertas | - | AC Juvenes/Dogana | 2:1 |  |
|||
| 17. Round | 06/04/2022 | SP Tre Penne | - | AC Juvenes/Dogana | 7:1 | ||||
| 30. Round | 20/04/2022 | AC Juvenes/Dogana | - | SP Tre Fiori | 0:3 |
San Marino