| 1. Round | 19/09/2021 | SS San Giovanni | - | AC Juvenes/Dogana | 4:0 | ||||
| 2. Round | 25/09/2021 | AC Juvenes/Dogana | - | SP Tre Penne | 0:1 | ||||
| 3. Round | 03/10/2021 | SS Folgore/Falciano | - | AC Juvenes/Dogana | 2:1 | ||||
| 5. Round | 19/10/2021 | AC Juvenes/Dogana | - | FC Domagnano | 2:1 | ||||
| 6. Round | 23/10/2021 | AC Juvenes/Dogana | - | FC Fiorentino | 0:1 | ||||
| 7. Round | 31/10/2021 | SP La Fiorita | - | AC Juvenes/Dogana | 2:2 | ||||
| 9. Round | 21/11/2021 | SC Faetano | - | AC Juvenes/Dogana | 3:1 | ||||
| 10. Round | 28/11/2021 | AC Juvenes/Dogana | - | SS Virtus | 1:2 |
San Marino