| 3. Round | 13/07/2020 | FC Milsami | - | Speranţa Nisporeni | 3:0 |  |
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| 4. Round | 18/07/2020 | Speranţa Nisporeni | - | Dinamo-Auto | 1:2 | ||||
| 5. Round | 22/07/2020 | FC Floreşti | - | Speranţa Nisporeni | 1:1 | ||||
| 6. Round | 25/07/2020 | Speranţa Nisporeni | - | CS Petrocub | 1:4 | ||||
| 7. Round | 31/07/2020 | Dacia Buiucani | - | Speranţa Nisporeni | 0:3 | ||||
| 8. Round | 04/08/2020 | FC Codru Lozova | - | Speranţa Nisporeni | 0:1 | |
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| 9. Round | 10/09/2020 | Speranţa Nisporeni | - | FC Sfîntul Gheorghe | 0:2 | ||||
| 10. Round | 18/09/2020 | Speranţa Nisporeni | - | FC Sheriff | 1:2 | |
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| 13. Round | 04/10/2020 | Dinamo-Auto | - | Speranţa Nisporeni | 3:3 | ||||
| 14. Round | 16/10/2020 | Speranţa Nisporeni | - | FC Floreşti | 0:0 | ||||
| 15. Round | 21/10/2020 | CS Petrocub | - | Speranţa Nisporeni | 2:0 | ||||
| 16. Round | 25/10/2020 | Speranţa Nisporeni | - | Dacia Buiucani | 0:0 | |
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| 18. Round | 06/11/2020 | FC Sfîntul Gheorghe | - | Speranţa Nisporeni | 1:0 | ||||
| 19. Round | 21/11/2020 | FC Sheriff | - | Speranţa Nisporeni | 3:0 | ||||
| 20. Round | 25/11/2020 | Speranţa Nisporeni | - | FC Zimbru | 2:2 |
Ukraine