| 3. Round | 22/01/2022 | LD Alajuelense | - | AD Guanacasteca | 4:0 | ||||
| 4. Round | 03/02/2022 | AD Guanacasteca | - | Municipal Grecia | 1:0 | ||||
| 5. Round | 09/02/2022 | AD Guanacasteca | - | Municipal Pérez Zeledón | 0:0 | ||||
| 6. Round | 15/02/2022 | AD San Carlos | - | AD Guanacasteca | 3:1 | ||||
| 7. Round | 20/02/2022 | AD Guanacasteca | - | Sporting FC | 2:0 | ||||
| 2. Round | 23/02/2022 | Jicaral | - | AD Guanacasteca | 2:2 | ||||
| 8. Round | 27/02/2022 | CS Herediano | - | AD Guanacasteca | 1:2 |  |
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| 9. Round | 02/03/2022 | Santos de Guápiles | - | AD Guanacasteca | 2:0 | ||||
| 10. Round | 06/03/2022 | AD Guanacasteca | - | CS Cartaginés | 1:1 | ||||
| 1. Round | 13/03/2022 | AD Guanacasteca | - | Deportivo Saprissa | 1:2 | ||||
| 11. Round | 01/04/2022 | AD Guanacasteca | - | Guadalupe | 1:2 | ||||
| 12. Round | 07/04/2022 | Deportivo Saprissa | - | AD Guanacasteca | 2:2 | ||||
| 13. Round | 09/04/2022 | AD Guanacasteca | - | Jicaral | 3:2 | ||||
| 14. Round | 16/04/2022 | AD Guanacasteca | - | LD Alajuelense | 0:3 | ||||
| 15. Round | 20/04/2022 | Municipal Grecia | - | AD Guanacasteca | 3:1 | ||||
| 16. Round | 24/04/2022 | Municipal Pérez Zeledón | - | AD Guanacasteca | 2:2 | ||||
| 17. Round | 27/04/2022 | AD Guanacasteca | - | AD San Carlos | 2:3 |
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