| 1. Round | 16/02/2019 | Montevideo Wanderers | - | River Plate | 1:1 | ||||
| 3. Round | 03/03/2019 | Boston River | - | River Plate | 2:0 | ||||
| 4. Round | 10/03/2019 | River Plate | - | Danubio | 1:1 | ||||
| 5. Round | 17/03/2019 | Plaza Colonia | - | River Plate | 1:0 |  |
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| 6. Round | 24/03/2019 | River Plate | - | CA Cerro | 2:1 | ||||
| 7. Round | 30/03/2019 | Cerro Largo | - | River Plate | 2:0 | ||||
| 8. Round | 06/04/2019 | Nacional | - | River Plate | 6:0 | ||||
| 9. Round | 14/04/2019 | River Plate | - | Fénix | 2:2 |  |
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| 10. Round | 20/04/2019 | Progreso | - | River Plate | 4:0 | ||||
| 11. Round | 04/05/2019 | River Plate | - | Peñarol | 0:2 | |
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| 14. Round | 25/05/2019 | Juventud de Las Piedras | - | River Plate | 4:1 | |
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| 15. Round | 02/06/2019 | River Plate | - | Liverpool | 0:0 |  |
Uruguay