| 3. Round | 29/07/2022 | Dinamo Zagreb | - | NK Istra 1961 | 4:1 | ||||
| 4. Round | 06/08/2022 | NK Istra 1961 | - | NK Osijek | 1:0 | ||||
| 5. Round | 12/08/2022 | HNK Šibenik | - | NK Istra 1961 | 0:0 | ||||
| 6. Round | 21/08/2022 | NK Istra 1961 | - | HNK Rijeka | 1:1 | ||||
| 7. Round | 26/08/2022 | HNK Gorica | - | NK Istra 1961 | 0:2 | ||||
| 8. Round | 04/09/2022 | NK Istra 1961 | - | Lokomotiva Zagreb | 1:2 |  |
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| 9. Round | 11/09/2022 | Slaven Belupo | - | NK Istra 1961 | 0:3 | ||||
| 10. Round | 17/09/2022 | Hajduk Split | - | NK Istra 1961 | 2:2 | ||||
| 11. Round | 30/09/2022 | NK Varaždin | - | NK Istra 1961 | 1:1 | ||||
| 13. Round | 15/10/2022 | NK Osijek | - | NK Istra 1961 | 2:0 | |
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| 14. Round | 23/10/2022 | NK Istra 1961 | - | HNK Šibenik | 0:0 | ||||
| 15. Round | 29/10/2022 | HNK Rijeka | - | NK Istra 1961 | 0:1 | |
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| 17. Round | 12/11/2022 | Lokomotiva Zagreb | - | NK Istra 1961 | 2:0 | ||||
| 18. Round | 20/01/2023 | NK Istra 1961 | - | Slaven Belupo | 0:0 | ||||
| 19. Round | 29/01/2023 | NK Istra 1961 | - | Hajduk Split | 3:0 | ||||
| 20. Round | 03/02/2023 | NK Istra 1961 | - | NK Varaždin | 2:1 | ||||
| 21. Round | 10/02/2023 | Dinamo Zagreb | - | NK Istra 1961 | 1:0 |
Croatia