| 1. Round | 19/02/2022 | Emelec | - | Macará | 4:0 |  |
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| 3. Round | 05/03/2022 | Emelec | - | Guayaquil City | 2:2 | |
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| 4. Round | 14/03/2022 | Gualaceo SC | - | Emelec | 2:1 |  |
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| 5. Round | 21/03/2022 | Emelec | - | Delfín SC | 1:2 | |
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| 6. Round | 02/04/2022 | Emelec | - | LDU Quito | 2:0 | ||||
| 7. Round | 10/04/2022 | Deportivo Cuenca | - | Emelec | 2:2 | |
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| 12. Round | 08/05/2022 | Emelec | - | Mushuc Runa | 4:0 | ||||
| 11. Round | 12/05/2022 | Barcelona | - | Emelec | 1:1 | ||||
| 13. Round | 15/05/2022 | Orense SC | - | Emelec | 2:0 | ||||
| 14. Round | 21/05/2022 | Emelec | - | Universidad Catolica | 0:1 | ||||
| 15. Round | 29/05/2022 | Técnico Universitario | - | Emelec | 1:1 |
Argentina