| 1. Round | 24/07/2021 | Club Necaxa | - | Santos Laguna | 0:3 |  |
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| 2. Round | 01/08/2021 | CF América | - | Club Necaxa | 2:1 | ||||
| 3. Round | 07/08/2021 | Club Necaxa | - | Cruz Azul | 1:2 | ||||
| 4. Round | 13/08/2021 | Atlético San Luis | - | Club Necaxa | 0:2 | ||||
| 6. Round | 23/08/2021 | Club Necaxa | - | FC Juárez | 1:0 | ||||
| 7. Round | 28/08/2021 | Deportivo Guadalajara | - | Club Necaxa | 2:1 | ||||
| 9. Round | 18/09/2021 | Club Necaxa | - | Atlas Guadalajara | 0:3 | ||||
| 10. Round | 24/09/2021 | CF Pachuca | - | Club Necaxa | 1:0 | ||||
| 11. Round | 28/09/2021 | Club Necaxa | - | Club Tijuana | 3:0 | ||||
| 12. Round | 04/10/2021 | UANL Tigres | - | Club Necaxa | 0:0 | ||||
| 13. Round | 16/10/2021 | Club Necaxa | - | Puebla FC | 0:1 | ||||
| 14. Round | 21/10/2021 | Deportivo Toluca | - | Club Necaxa | 1:1 | ||||
| 16. Round | 30/10/2021 | Club Necaxa | - | Mazatlán FC | 2:1 | ||||
| 17. Round | 06/11/2021 | Club León | - | Club Necaxa | 3:0 |
Argentina