| 5. Round | 10/09/2021 | Caernarfon Town | - | Cefn Druids | 3:0 | ||||
| 6. Round | 18/09/2021 | Cefn Druids | - | Penybont FC | 0:3 | ||||
| 7. Round | 02/10/2021 | Cardiff Metropolitan | - | Cefn Druids | 4:2 | ||||
| 10. Round | 23/10/2021 | Haverfordwest County | - | Cefn Druids | 2:1 | ||||
| 11. Round | 29/10/2021 | Connah's Quay Nomads | - | Cefn Druids | 4:0 | ||||
| 13. Round | 09/11/2021 | Cefn Druids | - | Flint Town United | 1:1 | ||||
| 14. Round | 20/11/2021 | Barry Town United | - | Cefn Druids | 1:0 | ||||
| 15. Round | 04/12/2021 | Cefn Druids | - | Cardiff Metropolitan | 1:3 |
Northern Ireland