| 4. Round | 22/08/2021 | FC Lausanne-Sport | - | FC Basel 1893 | 2:2 | ||||
| 5. Round | 29/08/2021 | FC Luzern | - | FC Lausanne-Sport | 1:1 | ||||
| 6. Round | 12/09/2021 | FC Lausanne-Sport | - | FC Sion | 1:1 | ||||
| 7. Round | 22/09/2021 | FC Lausanne-Sport | - | BSC Young Boys | 1:6 | ||||
| 9. Round | 02/10/2021 | FC Lugano | - | FC Lausanne-Sport | 2:0 | ||||
| 11. Round | 23/10/2021 | BSC Young Boys | - | FC Lausanne-Sport | 3:2 | ||||
| 12. Round | 31/10/2021 | FC Lausanne-Sport | - | FC Luzern | 1:1 | ||||
| 16. Round | 05/12/2021 | FC Basel 1893 | - | FC Lausanne-Sport | 1:1 | ||||
| 18. Round | 19/12/2021 | FC Sion | - | FC Lausanne-Sport | 2:0 | ||||
| 19. Round | 30/01/2022 | FC Lausanne-Sport | - | FC St. Gallen | 1:5 | ||||
| 20. Round | 05/02/2022 | Servette FC | - | FC Lausanne-Sport | 1:0 |  |
Costa Rica