| 1. Round | 16/08/2021 | Giresunspor | - | Galatasaray | 0:2 |  |
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| 2. Round | 23/08/2021 | Galatasaray | - | Hatayspor | 2:1 | ||||
| 3. Round | 29/08/2021 | Kasımpaşa SK | - | Galatasaray | 2:2 | ||||
| 6. Round | 22/09/2021 | Kayserispor | - | Galatasaray | 3:0 |  |
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| 7. Round | 26/09/2021 | Galatasaray | - | Göztepe | 2:1 | ||||
| 8. Round | 03/10/2021 | Çaykur Rizespor | - | Galatasaray | 2:3 | ||||
| 9. Round | 17/10/2021 | Galatasaray | - | Konyaspor | 1:0 | ||||
| 10. Round | 25/10/2021 | Beşiktaş | - | Galatasaray | 2:1 | ||||
| 12. Round | 07/11/2021 | Fatih Karagümrük | - | Galatasaray | 1:1 | ||||
| 13. Round | 21/11/2021 | Galatasaray | - | Fenerbahçe | 1:2 | ||||
| 14. Round | 28/11/2021 | Yeni Malatyaspor | - | Galatasaray | 0:0 | ||||
| 15. Round | 04/12/2021 | Galatasaray | - | Altay Izmir | 2:2 | |
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| 16. Round | 13/12/2021 | Sivasspor | - | Galatasaray | 1:0 | ||||
| 17. Round | 18/12/2021 | Galatasaray | - | İstanbul Başakşehir | 1:1 |
Senegal