| 1. Round | 11/09/2021 | KF Tiranë | - | KF Skënderbeu | 4:2 | ||||
| 2. Round | 18/09/2021 | KF Skënderbeu | - | FK Partizani | 1:1 | ||||
| 3. Round | 27/09/2021 | Egnatia Rrogozhine | - | KF Skënderbeu | 1:1 | ||||
| 4. Round | 02/10/2021 | KF Skënderbeu | - | FK Vllaznia | 0:0 | ||||
| 5. Round | 16/10/2021 | KS Kastrioti | - | KF Skënderbeu | 2:0 |  |
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| 9. Round | 21/11/2021 | KF Teuta Durrës | - | KF Skënderbeu | 2:2 |  |
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| 11. Round | 04/12/2021 | FK Partizani | - | KF Skënderbeu | 2:1 | ||||
| 12. Round | 08/12/2021 | KF Skënderbeu | - | Egnatia Rrogozhine | 2:0 | ||||
| 13. Round | 12/12/2021 | FK Vllaznia | - | KF Skënderbeu | 2:0 | ||||
| 14. Round | 18/12/2021 | KF Skënderbeu | - | KS Kastrioti | 2:1 | |
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| 16. Round | 15/01/2022 | KF Skënderbeu | - | KF Laçi | 0:0 | ||||
| 17. Round | 23/01/2022 | FK Kukësi | - | KF Skënderbeu | 1:0 | ||||
| 21. Round | 19/02/2022 | Egnatia Rrogozhine | - | KF Skënderbeu | 2:0 | ||||
| 22. Round | 25/02/2022 | KF Skënderbeu | - | FK Vllaznia | 2:2 | ||||
| 23. Round | 03/03/2022 | KS Kastrioti | - | KF Skënderbeu | 1:0 |  |
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| 29. Round | 17/04/2022 | FK Partizani | - | KF Skënderbeu | 0:0 | ||||
| 32. Round | 04/05/2022 | KF Skënderbeu | - | KS Kastrioti | 2:0 |
North Macedonia